It's always a compromise, isn't it?
I think heavier strings sound and keep in tune better but if you need to play styles with bends, it's better to use a second similar guitar with a lighter gauge with a plain third.
Hank used two Strats on the final tour after all....
I even used Hawaiian guitar sets years ago, which were very heavy. Good for the Who or Small Faces but no good for Cream or Hendrix...also, good for Buddy Holly or early Hank, but no good for James Burton stuff..
Barney Kessel told me he used 14-57 on his old guitar.
In the early days of solo and jazz rhythm guitar, guys used acoustic archtops with enormous gauges-- to be heard! It's been said that unless you used those big strings (often with a high action) the guitar would not respond and cut through the band. After all, it's really just physics...the heavy strings hit hard with high tension from a high action will really get the top moving and the sound really jumps out loud. Similar story with flat top acoustics, like J200s...
However, we are talking solid body guitars here, so back on topic! Get another guitar if you play in a number of styles..


